Rockland/AGAP2 Antibody/200-401-946/100 µg,Rockland,,Rockland,rockland-inc,Rockland Immunochemicals Inc,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Rockland/AGAP2 Antibody/200-401-946/100 µg

产品编号：200-401-946

市场价：¥7180.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>功能性抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$359.00

品牌： Rockland

公司：Rockland Immunochemicals Inc.

公司分类：

商品介绍

AGAP2AntibodyProperties

Description

Anti-AGAP2(RABBIT)Antibody-200-401-946

Host

Rabbit

TargetSpecies

Human

KnownCrossReactivity

human,mouse

Clonality

Polyclonal

Application

ELISA:1:40,000-1:200,000
WesternBlot:1:5,000-1:20,000
OtherDilution:UserOptimized

PhysicalState

Lyophilized

ShippingCondition

Ambient

Format

IgG

Label

Unconjugated

Concentration

2.0mg/mLbyUVabsorbanceat280nm

Buffer

0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2

ReconstitutionVolume

100µL

ReconstitutionBuffer

Restorewithdeionizedwater(orequivalent)

Preservative

0.01%(w/v)SodiumAzide

StABIlizer

None

GeneName

AGAP2

RelevantLinks

NCBI-7661962
UniProtKB-Q99490
GeneID-116986

AGAP2AntibodyDescription

Background

Thisantibodyisdesigned,produced,andvalidatedaspartofacollaborationbetweenRocklandandtheNationalCancerInstitute(NCI).AGAP2(alsoknownasArf-GAPwithGTPase,ANKrepeatandPHdomain-containingprotein2)isaGTPaseactivatingproteinthatinactivatesArf.TheexpressionofAGAP2isamplifiedinhumanglioblastomacells.GTPase-activatingprotein(GAP)forARF1andARF5,whichalsoshowsstrongGTPaseactivity.Itmediatesanti-apoptoticeffectsofnervegrowthfactorbyactivatingnuclearphosphoinositide3-kinase.Isoform1participatesinthepreventionofneuronalapoptosisbyenhancingPI3kinaseactivity.Itaidsthecouplingofmetabotropicglutamatereceptor1(GRM1)tocytoplasmicPI3kinasebyinteractingwithHomerscaffoldingproteins,andseemstomediateanti-apoptoticeffectsofNGFbyactivatingnuclearPI3kinase.Isoform2doesnotstimulatePI3kinasebutmayprotectcellsfromapoptosisbystimulatingAkt.Italsoregulatestheadapterprotein1(AP-1)-dependenttraffickingofproteinsintheendosomalsystem.Itseemstobeoncogenic.Itisoverexpressedincancercells,preventsapoptosisandpromotescancercellinvasion.Anti-AGAP2AntibodyisusefulforresearchersinterestedinDevelopmentalBIOLOGy,apoptosis,Cancer,Immunology,andNuclearSignalingresearch.

Synonyms

rabbitanti-AGAP2antibody,AGAP-2,AGAP2,Arf-GAPwithGTPase,ANKrepeatandPHdomain-containingprotein2antibody,ArfGAPwithGTPasedomain,ankyrinrepeatandPHdomain2antibody,centauringamma1antibody,Centg1antibody

Immunogen

ThisproteinApurifiedantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswitharecombinantproteincorrespondingtoaminoacids1-836ofhumanAGAP2protein.

ImmunogenType

RecombinantProtein

StorageCondition

Storevialat4°Cpriortorestoration. Forextendedstoragealiquotcontentsandfreezeat-20°Corbelow. Avoidcyclesoffreezingandthawing. Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature. Thisproductisstableforseveralweeksat4°Casanundilutedliquid. Diluteonlypriortoimmediateuse.

ApplicationNote

ThisproteinApurifiedantibodyhasbeentestedforuseinELISAandwesternblot. Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandapproximately90kDainsizecorrespondingtoAGAP2proteinbywesternblottingintheappropriatecelllysateorextract.

Purity/Specifity

ThisproteinApurifiedantibodyisdirectedagainsthumanAGAP2protein.TheproductwaspurifiedfrommonospecificantiserumbyproteinAchromatography. ABLASTanalysiswasusedtosuggestcrossreactivitywithAGAP2proteinfrommouseandratbasedon93%and95%protein:proteinhomologies,respectively,withtheimmunizingsequence. Reactivityagainsthomologuesfromothersourcesisnotknown.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

品牌介绍

ROCKLAND

Rockland Immunochemicals Inc. 成立于1962年，是一家全球性的生物技术公司，为功能基因组学，基因治疗和药物发现市场的基础，应用和临床研究制造领先的研究工具。

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