Rockland/ALKBH2 Antibody/600-401-Y05/100 µg,Rockland,,Rockland,rockland-inc,Rockland Immunochemicals Inc,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Rockland/ALKBH2 Antibody/600-401-Y05/100 µg

产品编号：600-401-Y05

市场价：¥7180.00

场地：美国(厂家直采)

产品分类：细胞相关>细胞研究>细胞凋亡>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$359.00

品牌： Rockland

公司：Rockland Immunochemicals Inc.

公司分类：

商品介绍

ALKBH2AntibodyProperties

Description

Anti-ALKBH2(RABBIT)Antibody-600-401-Y05

Host

Rabbit

TargetSpecies

Human

KnownCrossReactivity

Human,mouse,rat

Clonality

Polyclonal

Application

ELISA:1:10,000-1:20,000
WesternBlot:1-2µg/mL
Immunohistochemistry:10µg/mL

PhysicalState

Liquid(sterilefiltered)

ShippingCondition

DryIce

Format

IgG

Label

Unconjugated

Concentration

1mg/mLbyUVabsorbanceat280nm

Buffer

0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2

Preservative

0.02%(w/v)SodiumAzide

StABIlizer

None

GeneName

ALKBH2

RelevantLinks

UniProtKB-Q6NS38
GeneID-121642
NCBI-NP_001138847

ALKBH2AntibodyDescription

Background

TheE.coliAlkBproteinprotectsagainstthecytotoxicityofmethylatingagentsbyrepairofthespecificDNAlesionsgeneratedinsingle-strandedDNA;ALKBH2andALKBH3aremammalianhomologsofAlkBthatcatalyzetheremovalof1-methyladenineand3-methylcytosine,modificationsthatleftuncheckedcouldleadtocancerouscells.MutationsinbothALKBH2andALKBH3havebeenobservedinpediatricbraintumorsindicatingthattheseproteinsareimportantinthepreventionofcancerformation.LikethehistonedemethylaseJMJD1A,ALKBH2isanon-hemeironenzymethatisinhibitedbyNickelions,suggestingthatinhibitionofALKBH2byNickelionsmayplayaroleinthedevelopmentofcancer.Conversely,ALKBH2mRNAandproteinlevelsareincreasedgliomacellsfollowingPhotofrin-mediatedphotodynamictherapy,anadjuvanttherapyincancertreatment,suggestingthatdown-regulatingALKBH2expressionincancercellsmayenhancetheanti-cancereffectivenessofthistreatment.

Synonyms

ALKBH2Antibody,ABH2,ABH2,Alpha-ketoglutarate-dependentdioxygenasealkBhomolog2,AlkylatedDNArepairproteinalkBhomolog2

Immunogen

Anti-ALKBH2antibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswitha15aminoacidsyntheticpeptideneartheC-terminusofhumanALKBH2.

ImmunogenType

Peptide

StorageCondition

Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.

ApplicationNote

Anti-ALKBH2AntibodyhasbeentestedforuseinELISA,WesternBlotting,andImmunohistochemistry.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandatapproximately29kDainWesternBlotsofspecificcelllysatesandtissues.

Purity/Specifity

Anti-ALKBH2Antibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.CrossreactivitywithALKBH2fromothersourceshasnotbeendetermined.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

品牌介绍

ROCKLAND

Rockland Immunochemicals Inc. 成立于1962年，是一家全球性的生物技术公司，为功能基因组学，基因治疗和药物发现市场的基础，应用和临床研究制造领先的研究工具。

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