Rockland/AIF Antibody/200-401-985/100 µg,Rockland,,Rockland,rockland-inc,Rockland Immunochemicals Inc,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Rockland/AIF Antibody/200-401-985/100 µg

产品编号：200-401-985

市场价：¥7180.00

场地：美国(厂家直采)

产品分类：细胞相关>细胞研究>细胞凋亡>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$359.00

品牌： Rockland

公司：Rockland Immunochemicals Inc.

公司分类：

商品介绍

AIFAntibodyProperties

Description

Anti-ApoptosisInducingFactor(AIF)(RABBIT)Antibody-200-401-985

Host

Rabbit

TargetSpecies

Human

KnownCrossReactivity

human,mouse,rat

Clonality

Polyclonal

Application

ELISA:UserOptimized
WesternBlot:0.25-1µg/ml
Immunohistochemistry:10µg/ml
OtherDilution:UserOptimized

PhysicalState

Liquid(sterilefiltered)

ShippingCondition

DryIce

Format

IgG

Label

Unconjugated

Concentration

0.5mg/mLbyUVabsorbanceat280nm

Buffer

0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2

Preservative

0.01%(w/v)SodiumAzide

StABIlizer

None

GeneName

AIFM1

RelevantLinks

UniProtKB-O95831
NCBI-13431764
GeneID-9131

AIFAntibodyDescription

Background

Apoptosisischaracterizedbyseveralmorphologicalnuclearchangesincludingchromatincondensationandnuclearfragmentation. Thesechangesaretriggeredbytheactivationofmembersofthecaspasefamily,caspaseactivatedDNase,andseveralnovelproteins. Anovelgene,theproductofwhichcauseschromatincondensationandDNAfragmentation,wasrecentlyidentified,cloned,anddesignatedapoptosisinducingfactor(AIF). Likecytochromecandcaspase-9,whicharecriticalmoleculesinapoptosis,AIFlocalizestomitochondria. AIFtranslocatestothenucleuswhenapoptosisisinducedandinducesmitochondriatoreleasetheapoptogenicproteinscytochromecandcaspase-9. AIFinduceschromatincondensationandlargescaleDNAfragmentation,whicharethehallmarksofapoptosis. Theseeffectsoccurinbothisolatednucleiandinthenucleioflivecellstreatedbymicroinjectionandwithapoptosisstimuli. AIFishighlyconservedbetweenhumanandmouseandiswidelyexpressed.Anti-AIFantibodyisidealforinvestigatorsinvolvedinDNADamageandRepairandChromatinresearch.

Synonyms

Harlequinantibody,Hqantibody,mAIFantibody,MGC111425antibody,MGC5706antibody,PDCD8antibody,AIF,PDCD8

Immunogen

AIFAntibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingtoaminoacidsataninternalregionofhumanAIFprotein.

ImmunogenType

Peptide

StorageCondition

Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.

ApplicationNote

Anti-AIFAntibodyhasbeentestedforuseinELISA,westernblottingandimmunohistochemistry. K562celllysate,aswellasratandmousehearttissuelysates,canbeusedaspositivecontrolsinwesternblotting,andabandatapproximately67kDaisexpected. Specificconditionsforreactivityshouldbeoptimizedbytheenduser.

Purity/Specifity

Anti-AIFAntibodyisdirectedagainsthumanAIFprotein. TheproductwaspurifiedfrommonospecificantiserumbyDEAEionexchangechromatography. ABLASTanalysiswasusedtosuggestcross-reactivitywithAIFproteinfrommouseandratbasedon100%homologywiththeimmunizingsequence.Reactivityagainsthomologuesfromothersourcesisnotknown.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

品牌介绍

ROCKLAND

Rockland Immunochemicals Inc. 成立于1962年，是一家全球性的生物技术公司，为功能基因组学，基因治疗和药物发现市场的基础，应用和临床研究制造领先的研究工具。

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