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主营:antibodies ,dpolyclonal
℡ 4000-520-616
℡ 4000-520-616
Rockland/AIF Antibody/200-401-985/100 µg
产品编号:200-401-985
市  场 价:¥7180.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$359.00
品      牌: Rockland
公      司:Rockland Immunochemicals Inc.
公司分类:
Rockland/AIF Antibody/200-401-985/100 µg
商品介绍

AIFAntibodyProperties

Description
Anti-ApoptosisInducingFactor(AIF)(RABBIT)Antibody-200-401-985
Host
Rabbit
TargetSpecies
Human
KnownCrossReactivity
human,mouse,rat
Clonality
Polyclonal
Application
ELISA:UserOptimized
WesternBlot:0.25-1µg/ml
Immunohistochemistry:10µg/ml
OtherDilution:UserOptimized
PhysicalState
Liquid(sterilefiltered)
ShippingCondition
DryIce
Format
IgG
Label
Unconjugated
Concentration
0.5mg/mLbyUVabsorbanceat280nm
Buffer
0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2
Preservative
0.01%(w/v)SodiumAzide
StABIlizer
None
GeneName
AIFM1
RelevantLinks
UniProtKB-O95831
NCBI-13431764
GeneID-9131

AIFAntibodyDescription

Background
Apoptosisischaracterizedbyseveralmorphologicalnuclearchangesincludingchromatincondensationandnuclearfragmentation. Thesechangesaretriggeredbytheactivationofmembersofthecaspasefamily,caspaseactivatedDNase,andseveralnovelproteins. Anovelgene,theproductofwhichcauseschromatincondensationandDNAfragmentation,wasrecentlyidentified,cloned,anddesignatedapoptosisinducingfactor(AIF). Likecytochromecandcaspase-9,whicharecriticalmoleculesinapoptosis,AIFlocalizestomitochondria. AIFtranslocatestothenucleuswhenapoptosisisinducedandinducesmitochondriatoreleasetheapoptogenicproteinscytochromecandcaspase-9. AIFinduceschromatincondensationandlargescaleDNAfragmentation,whicharethehallmarksofapoptosis. Theseeffectsoccurinbothisolatednucleiandinthenucleioflivecellstreatedbymicroinjectionandwithapoptosisstimuli. AIFishighlyconservedbetweenhumanandmouseandiswidelyexpressed.Anti-AIFantibodyisidealforinvestigatorsinvolvedinDNADamageandRepairandChromatinresearch.
Synonyms
Harlequinantibody,Hqantibody,mAIFantibody,MGC111425antibody,MGC5706antibody,PDCD8antibody,AIF,PDCD8
Immunogen
AIFAntibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingtoaminoacidsataninternalregionofhumanAIFprotein.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-AIFAntibodyhasbeentestedforuseinELISA,westernblottingandimmunohistochemistry. K562celllysate,aswellasratandmousehearttissuelysates,canbeusedaspositivecontrolsinwesternblotting,andabandatapproximately67kDaisexpected. Specificconditionsforreactivityshouldbeoptimizedbytheenduser.
Purity/Specifity
Anti-AIFAntibodyisdirectedagainsthumanAIFprotein. TheproductwaspurifiedfrommonospecificantiserumbyDEAEionexchangechromatography. ABLASTanalysiswasusedtosuggestcross-reactivitywithAIFproteinfrommouseandratbasedon100%homologywiththeimmunizingsequence.Reactivityagainsthomologuesfromothersourcesisnotknown.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
品牌介绍

ROCKLAND


Rockland Immunochemicals Inc. 成立于1962年,是一家全球性的生物技术公司,为功能基因组学,基因治疗和药物发现市场的基础,应用和临床研究制造领先的研究工具。


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