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主营:antibodies ,dpolyclonal
℡ 4000-520-616
℡ 4000-520-616
Rockland/ARF-BP1 Antibody/600-401-C03/100 µg
产品编号:600-401-C03
市  场 价:¥7180.00
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$359.00
品      牌: Rockland
公      司:Rockland Immunochemicals Inc.
公司分类:
Rockland/ARF-BP1 Antibody/600-401-C03/100 µg
商品介绍

ARF-BP1AntibodyProperties

Description
Anti-ARF-BP1(Rabbit)Antibody-600-401-C03
Host
Rabbit
TargetSpecies
Human
KnownCrossReactivity
Human,mouse,rat
Clonality
Polyclonal
Application
ELISA:1:10,000-1:40,000
IFMicroscopy:5.0µg/mL
WesternBlot:1.0-2.0µg/mL
OtherDilution:UserOptimized
PhysicalState
Liquid(sterilefiltered)
ShippingCondition
DryIce
Format
IgG
Label
Unconjugated
Concentration
1.0mg/mLbyUVabsorbanceat280nm
Buffer
0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2
Preservative
0.01%(w/v)SodiumAzide
StABIlizer
None
GeneName
HUWE1
RelevantLinks
UniProtKB-Q7Z6Z7
NCBI-NP_113584.3
GeneID-10075

ARF-BP1AntibodyDescription

Background
TheARFtumorsuppressorisacriticalregulatorofp53stability.Inadditiontop53,ARF1bindstootherproteinssuchasMDM2andARF-BP1,alargeproteincontainingHECT,UBAandWWEmotifs.ARF-BP1directlybindsandubiquitinatesp53;thisactivityisinhibitedbyARF,indicatingthatARF-BP1isacriticalmediatorofthep53-dependentandp53-independenttumorsuppressorfunctionsofARF.ARF-BP1canalsocatalyzethepolyubiquitinationofMcl-1,ananti-apoptoticBcl-2familymemberinvolvedinDNAdamage-inducedapoptosis.EliminationofARF-BP1expressionbyRNAinterferencestabilizedMcl-1protein,resultinginanattenuationofapoptosisinducedbyDNA-damageagents.Anti-ARF-BP1antibodyisidealforinvestigatorsinvolvedincancerresearch.
Synonyms
ARF-BP1,ARFbindingprotein1;HECT,UBAandWWEdomaincontaining1;HUWE1;Mcl-1ubiquitinligaseE3;Mule;E3ubiquitin-proteinligaseHUWE1,KIAA0312,KIAA1578,UREB1
Immunogen
ARF-BP1AntibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingtoaregionnearthecarboxyterminusofhumanARF-BP1protein.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
ARF-BP1antibodyhasbeentestedinELISA,WB,andICC.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandat~481kDainsizecorrespondingtoARF-BP1byWesternblottingintheappropriatecelllysateorextract.Daudicelllysatecanbeusedaspositivecontrol.
Purity/Specifity
Anti-ARF-BP1Antibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitypurification.ABLASTanalysiswasusedtosuggestcross-reactivitywithARF-BP1withHuman,RatandMousebasedon100%homologywiththeimmunizingsequence.Cross-reactivitywithARF-BP1fromothersourceshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
品牌介绍

ROCKLAND


Rockland Immunochemicals Inc. 成立于1962年,是一家全球性的生物技术公司,为功能基因组学,基因治疗和药物发现市场的基础,应用和临床研究制造领先的研究工具。


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