Rockland/Apaf1 Antibody/600-401-Y27/100 µg,Rockland,,Rockland,rockland-inc,Rockland Immunochemicals Inc,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Rockland/Apaf1 Antibody/600-401-Y27/100 µg

产品编号：600-401-Y27

市场价：¥7180.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>功能性抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$359.00

品牌： Rockland

公司：Rockland Immunochemicals Inc.

公司分类：

商品介绍

Apaf1 Antibody Properties

Description

Anti-Apaf1 (RABBIT) Antibody - 600-401-Y27

Host

Rabbit

Target Species

Human

Known Cross Reactivity

Human, mouse, rat

Clonality

Polyclonal

Application

ELISA : 1:10,000
Western Blot : 1 µg/mL
Immunohistochemistry: 20 µg/mL

Physical State

Liquid (sterile filtered)

Shipping Condition

Dry Ice

Format

IgG

Label

Unconjugated

Concentration

1 mg/mL by UV absorbance at 280 nm

Buffer

0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2

Preservative

0.02% (w/v) Sodium Azide

Stabilizer

None

GeneName

APAF1

Relevant Links

UniProtKB - O14727
GeneID - 317
NCBI - AAC51678

Apaf1 Antibody Description

Background

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologous of the key cell death gene CED-4 in C. elegans was identified recently from human and mouse and designated Apaf1 for apoptosis protease-activating factor 1. Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 transcript is ubiquitously expressed in human tissues.

Synonyms

Apaf1 Antibody, CED4, APAF-1, KIAA0413, Apoptotic protease-activating factor 1

Immunogen

Anti-Apaf1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to amino acids near the C-terminus of human Apaf1. The sequence of the immunogenic peptide differs from that of murine Apaf1 by one amino acid.

Immunogen Type

Peptide

Storage Condition

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Application Note

Anti-Apaf1 Antibody has been tested for use in ELISA, Western Blotting, and Immunohistochemistry. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 142 kDa in Western Blots of specific cell lysates and tissues.

Purity/Specifity

Anti-Apaf1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Apaf1 from other sources has not been determined.

Disclaimer Note-General

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

品牌介绍

ROCKLAND

Rockland Immunochemicals Inc. 成立于1962年，是一家全球性的生物技术公司，为功能基因组学，基因治疗和药物发现市场的基础，应用和临床研究制造领先的研究工具。

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