Rockland/Androgen Receptor Antibody/200-301-H54/100 µg,Rockland,,Rockland,rockland-inc,Rockland Immunochemicals Inc,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Rockland/Androgen Receptor Antibody/200-301-H54/100 µg

产品编号：200-301-H54

市场价：¥7780.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>功能性抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$389.00

品牌： Rockland

公司：Rockland Immunochemicals Inc.

公司分类：

商品介绍

AndrogenReceptorAntibodyProperties

Description

Anti-AndrogenReceptor(MOUSE)MonoclonalAntibody-200-301-H54

Host

Mouse

TargetSpecies

Human

KnownCrossReactivity

Human

Clonality

Monoclonal156C135.2IgG1kappa

Application

WesternBlot:1-4µg/mL
Immunohistochemistry:UserOptimized

PhysicalState

Liquid

ShippingCondition

DryIce

Format

IgG1

Label

Unconjugated

Concentration

0.5mg/mLbyUVabsorbanceat280nm

Buffer

0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2

Preservative

0.05%(w/v)SodiumAzide

StABIlizer

0.05%BSA

GeneName

RelevantLinks

UniProtKB-P10275
NCBI-NP_000035.2
GeneID-367

AndrogenReceptorAntibodyDescription

Background

Anti-AndrogenReceptorAntibodydetectshumanAndrogenreceptor.Theandrogenreceptor(AR)isan~110kDaandrogen-dependenttranscriptionfactorthatisamemberofthesteroid/nuclearreceptorgenesuperfamily.TheARsignalingpathwayplaysakeyroleindevelopmentandfunctionofmalereproductiveorgans,includingtheprostateandepididymis.ARalsoplaysaroleinnonreproductiveorgans,suchasmuscle,hairfollicles,andbrain.AbnormalitiesintheARsignalingpathwayhavebeenlinkedtoanumberofdiseases,includingprostatecancer,Kennedy"sdiseaseandmaleinfertility.ThePI3K/AktsignalingpathwayplaysanimportantroleinregulatingARactivitythroughphosphorylationofARatSer213/210andSer791/790.GrowthfactorsorcytokinesmayinducephosphorylationofARthroughthePI3K/Aktpathway.IGF-1activatesthephosphatidylinositol3-kinase(PI3K)/AKTpathwayinLNCapathighpassagenumberandincreasesphosphorylationofofARatSer213/210(seewesternblot)andSer791/790.ThewesternblotresultsalsoshowthatinhibitionofthePI3K/AktpathwaybyLY294002priortoincubationwithIGF-1suppressedARphosphorylationatSer213/210.ActivationofthePI3K/AKtpathwayisthoughttohaveasurvivalroleinprostatecancerbyprotectingcellsfromapoptosis.Anti-AndrogenReceptorAntibodyisidealforinvestigatorsinvolvedinneuroscience,cytokinesandgrowthfactors,andtranscriptionfactors.

Synonyms

DHTR,NR3C4

Immunogen

AndrogenReceptorAntibodywasproducedinmicebyrepeatedimmunizationswithasyntheticpeptidecorrespondingtoaminoacidsnearthen-terminusoftheAndrogenReceptor.

ImmunogenType

Peptide

StorageCondition

Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.

ApplicationNote

Anti-AndrogenReceptorAntibodyissuitbaleforuseinIHC(p)andWB.Expectabandapproximately110kDaonspecificlysates.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.

Purity/Specifity

Anti-AndrogenReceptorAntibodywaspurifiedbyProteinGchromatography.ABLASTanalysiswasusedtosuggestcross-reactivitywithAnti-AndrogenReceptorfromhumanandNewWorldMonkeyon100%homologywiththeimmunizingsequence.Cross-reactivitywithAnti-AndrogenReceptorfromothersourceshasnotbeendetermined.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

品牌介绍

ROCKLAND

Rockland Immunochemicals Inc. 成立于1962年，是一家全球性的生物技术公司，为功能基因组学，基因治疗和药物发现市场的基础，应用和临床研究制造领先的研究工具。

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