Rockland/Ago Antibody/200-301-V04/50 µg,Rockland,,Rockland,rockland-inc,Rockland Immunochemicals Inc,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Rockland/Ago Antibody/200-301-V04/50 µg

产品编号：200-301-V04

市场价：¥7180.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>功能性抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$359.00

品牌： Rockland

公司：Rockland Immunochemicals Inc.

公司分类：

商品介绍

AgoAntibodyProperties

Description

Anti-Ago(Argonautes)(MOUSE)MonoclonalAntibody-200-301-V04

Host

Mouse

TargetSpecies

Human

KnownCrossReactivity

Human,Mouse,Other(widerange)

Clonality

Monoclonal2A8IgG1

Application

IFMicroscopy:1:500
WesternBlot:1:300-1:500
Immunohistochemistry:1:500
ImmunoPrecipitation:8µg
OtherDilution:HITS-CLIP:UserOptimizedDilution

PhysicalState

Liquid(sterilefiltered)

ShippingCondition

DryIce

Format

IgG1

Label

Unconjugated

Concentration

2.0mg/mlbyUVabsorbanceat280nm

Buffer

0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2

Preservative

0.05%(w/v)SodiumAzide

StABIlizer

None

GeneName

AGO2

RelevantLinks

UniProtKB-Q9UKV8
GeneID-27161
NCBI-NP_001158095

AgoAntibodyDescription

Background

MembersoftheArgonaute(Ago)proteinfamilyareinternaltoRISCfunction.ArgonauteproteinsbindtomaturemicroRNA(miRNAs)andshortinterferingRNAs(siRNAs)andformthecorecomponentsofeffectorcomplexesthatmediatemiRNAandsiRNAfunction.ArgonautesareneededformiRNA-inducedsilencingandcontaintwoconservedRNAbindingdomains:aPAZdomainthatcanbindthesinglestranded3’endofthematuremiRNAandaPIWIdomainthatstructurallyresemblesribonuclease-Handfunctionstointeractwiththe5’endoftheguidestrand.Someargonautes,forexamplehumanAgo2,cleavetargettranscriptsdirectly;argonautesmayalsorecruitadditionalproteinstoachievetranslationalrepression.ThehumangenomeencodeseightArgonauteproteinsdividedbysequencesimilaritiesintotwofamilies:AGO(withfourmemberspresentinallmammaliancellsandcalledE1F2C/hAgoinhumans),andPIWI(foundinthegermlineandhematopoieticstemcells).Anti-AgoAntibodyisidealforresearchinAlternativeSplicing,GeneExpressionandGeneSilencing.

Synonyms

Proteinargonaute-2,Argonaute2,hAgo2,ArgonauteRISCcatalyticcomponent2,Eukaryotictranslationinitiationfactor2C2,eIF-2C2,eIF2C2,PAZPiwidomainprotein,PPD,Proteinslicer

Immunogen

Anti-AgoAntibodywasproducedinmicebyrepeatedimmunizationwithhumanAgo2protein(fusionproteincontainingaminoacids47-859ofhumanAgo2).

ImmunogenType

Peptide

StorageCondition

Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.

ApplicationNote

Anti-AgoAntibodyissuitableforHITS-CLIP(High-throughputsequencingofRNAisolatedbycrosslinkingimmunoprecipitation),Immunofluorescence,Immunohistochemistry,ImmunoprecipitationandWesternBlots.Specificconditionsforreactivityshouldbeoptimizedbytheenduser. Expectabandapproximately97.2kDaintheappropriatecelllysateorextract.

Purity/Specifity

Anti-AgoAntibodywaspurifiedbyProteinAchromatography.This2A8monoclonalantibodyrecognizesall4humanandmouseAgoproteinswhilehavinghigheraffinityforAgo2.Cross-reactivitywithAgo2fromothersourceshasnotbeendetermined.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

品牌介绍

ROCKLAND

Rockland Immunochemicals Inc. 成立于1962年，是一家全球性的生物技术公司，为功能基因组学，基因治疗和药物发现市场的基础，应用和临床研究制造领先的研究工具。

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