Rockland/8-Hydroxy Guanine Antibody/200-301-A99/100 µg,Rockland,,Rockland,rockland-inc,Rockland Immunochemicals Inc,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Rockland/8-Hydroxy Guanine Antibody/200-301-A99/100 µg

产品编号：200-301-A99

市场价：¥7180.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>功能性抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$359.00

品牌： Rockland

公司：Rockland Immunochemicals Inc.

公司分类：

商品介绍

8-HydroxyGuanineAntibodyProperties

Description

Anti-8-HydroxyGuanine(MOUSE)MonoclonalAntibody-200-301-A99

Host

Mouse

KnownCrossReactivity

8hydroxy2’deoxyguanosine,8-hydroxyguanineand8-hydroxyguanosine

Clonality

Monoclonal15A3IgG2a

Application

ELISA:1:20,000
Immunohistochemistry:20ug/ml
OtherDilution:UserOptimized

PhysicalState

Liquid(sterilefiltered)

ShippingCondition

DryIce

Format

IgG2a

Label

Unconjugated

Concentration

1.0mg/mLbyUVabsorbanceat280nm

Buffer

0.01MSodiumPhosphate,0.15MSodiumChloride,pH7.2

Preservative

0.1%(w/v)SodiumAzide

StABIlizer

50%(v/v)Glycerol

8-HydroxyGuanineAntibodyDescription

Background

DNAorRNAdamageisduetoenvironmentalfactorsandnormalmetabolicprocessesinsidethecell,thatthenhindertheabilityofthecelltocarryoutitsfunctions.TherearefourmaintypesofDNAdamageduetoendogenouscellularprocesses:oxidation,alkylation,hydrolysisandmismatchofthebases.Duringtheoxidationofbases,highlyreactivechemicalentitiescollectivelyknownasRONSmaydevelop.RONSstandsforreactiveoxygenandnitrogenspeciesandincludesnitricoxide,superoxide,hydroxylrADIcal,hydrogenperoxideandperoxynitrite.NumerousstudieshaveshownthatRONScauseavarietyofotherissuesinadditiontoDNAdamage(1).8-hydroxyguanine,8-hydroxy-2’-deoxyguanosineand8-hydroxyguanosineareallRNAandDNAMarkersofoxidativedamage.8-hydroxy-2’-guanosineisproducedbyreactiveoxygenandnitrogenspeciesincludinghydroxylradicalandperoxynitrite.SpecificallyitshighBIOLOGicalrelevanceisduetoitsabilitytoinduceGtoTtransversions,whichisoneofthemostfrequentsomaticmutations(2).8-hydroxy-guaninehasbeenthemostfrequentlystudiedtypeofDNAbasedamage,withstudiesindiabetes,andcancer.Basemodificationsofthistypearisefromradical-inducedhydroxylationandcleavagereactionsofthepurinering(3,4).Finally,8-hydroxy-guanosine,like8-hydroxy-2’-guanosine,inducesamutagenictransversionofGtoTinDNA.Itsrolehasbeentestedspecificallyinthedevelopmentofdiabetes,hypertensionandstrokes(5,6,and7).

Synonyms

8hydroxy2’deoxyguanosineantibody,8hydroxyguanineantibody,8hydroxyguanosineantibody,8OHGantibody,8-OHGantibody,8OGantibody,8OHdGantibody,8OHGantibody

Immunogen

ThisProteinGpurifiedmonoclonalantibodywaspreparedusingconventionalhybridomatechnologyafterrepeatedimmunizationswith8-hydroxy-guanosine-BSAandcaseinconjugates.

ImmunogenType

NativeProtein

StorageCondition

StoreAnti-8-HydroxyGuanineantibodyat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.

ApplicationNote

ThisProteinGpurifiedantibodyhasbeentestedforuseinimmunohistochemistryandELISA. Specificconditionsforreactivityshouldbeoptimizedbytheenduser.

Purity/Specifity

ThisProteinGpurifiedAnti-8-HydroxyGuaninemonoclonalantibodyrecognizesmarkersofoxidativedamagetoDNA(8-hydroxy-2"-deoxyguanosine,8-hydroxyguanineand8-hydroxyguanosine).

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

品牌介绍

ROCKLAND

Rockland Immunochemicals Inc. 成立于1962年，是一家全球性的生物技术公司，为功能基因组学，基因治疗和药物发现市场的基础，应用和临床研究制造领先的研究工具。

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