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主营:antibodies ,dpolyclonal
℡ 4000-520-616
℡ 4000-520-616
Rockland/AKT2 Antibody/600-401-425/100 µg
产品编号:600-401-425
市  场 价:¥7180.00
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$359.00
品      牌: Rockland
公      司:Rockland Immunochemicals Inc.
公司分类:
Rockland/AKT2 Antibody/600-401-425/100 µg
商品介绍

AKT2AntibodyProperties

Description
Anti-AKT2(RABBIT)Antibody-600-401-425
Host
Rabbit
TargetSpecies
Human
KnownCrossReactivity
human
Clonality
Polyclonal
Application
ELISA:1:4000-1:16000
FlowCytometry:UserOptimized
WesternBlot:1:1000
OtherDilution:UserOptimized
PhysicalState
Liquid(sterilefiltered)
ShippingCondition
DryIce
Format
IgG
Label
Unconjugated
Concentration
1.0mg/mLbyUVabsorbanceat280nm
Buffer
0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2
Preservative
0.01%(w/v)SodiumAzide
StABIlizer
None
GeneName
AKT2
RelevantLinks
UniProtKB-P31751
GeneID-208
GeneID-164731

AKT2AntibodyDescription

Background
AKT2isalsoknownasV-AKTMurineThymomaViralOncogeneHomolog2antibody,Racproteinkinasebetaantibody,PKBbetaantibodyorPRKBBantibody. AKT2isanisoformofthephosphoinositide-dependentserine-threonineproteinkinaseAKTandisenrichedininsulin-responsivetissuesandhasbeenimplicatedinthemetabolicactionsofthehormone. AKT2isaputativeoncogeneencodingaproteinbelongingtoasubfamilyofserine/threoninekinasescontainingSH2-like(Srchomology2-like)domains.FurThermore,AKT2wasshowntobeamplifiedandoverexpressedin2of8ovariancarcinomacelllinesand2of15primaryovariantumors.Over-expressionofAKT2contributestothemalignantphenotypeofasubsetofhumanductalpancreaticcancers.AKT2isageneralproteinkinasecapableofphophorylatingseveralknownproteins. AKT2mediatesmanyofthedownstreameventsofPI3-kinase(alipidkinaseactivatedbygrowthfactors,cytokinesandinsulin). PI3-kinaserecruitsAKT2tothemembrane,whereitisactivatedbyPDK1phosphorylation.Oncephosphorylated,AKT2dissociatesfromthemembraneandphosphorylatestargetsinthecytoplasmandthecellnucleus. AKT2hastwomainroles:(i)inhibitionofapoptosis;(ii)promotionofproliferation.
Synonyms
rabbitanti-AKT2antibody,AKT2,AKT-2,PKBantibody,PKBbetaantibody,PKBBETAantibody,PRKBBantibody,ProteinkinaseAkt2antibody,ProteinkinaseBbetaantibody,RAC-betaserine/threonine-proteinkinase,RAC-PK-beta
Immunogen
Thisaffinitypurifiedantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingtoaa455-468(of481)ofhumanAKT2conjugatedtoKeyholeLimpetHemocyanin(KLH).
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
ThisantibodywastestedbyELISAandimmunoblottingandwasfoundtobereactivewithbothunphosphorylatedandphosphorylatedAKT2inalysateofHEK293cells. Althoughnottested,thisantibodyislikelyfunctionalinimmunohistochemistryandimmunoprecipitation.ThisproducthasbeenassayedbyimmunoblotagainstaHEK293celllysateandisreactiveata1:1,000dilutionshowingabandatapproximately60kDa.  Aworkingdilutionof1:4,000to1:16,000issuggestedforthisproductinastandardcaptureELISAusingTMB(3,3",5,5"-Tetramethylbenizidine)code#TMBE-100asasubstratefor30minutesatroomtemperatureagainst0.1ugoftheimmunizingpeptide.Researchersshoulddetermineoptimaltitersforotherapplications.
Purity/Specifity
ThisaffinitypurifiedantibodyisdirectedagainsthumanAKT2.Theantibodydetectsbothunphosphorylatedandphosphorylatedformsoftheprotein.Theproductwasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitypurification. CrossreactivitywithAKT2fromotherspecieshasnotbeendetermined,however,thesequenceoftheimmunogenshows85%identitytomouseand92%identitywithrat,therefore,crossreactivityisexpected.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
品牌介绍

ROCKLAND


Rockland Immunochemicals Inc. 成立于1962年,是一家全球性的生物技术公司,为功能基因组学,基因治疗和药物发现市场的基础,应用和临床研究制造领先的研究工具。


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